Tapentadol is a medication used to treat moderate to severe pain. It is a synthetic opioid analgesic and is structurally related to tramadol. Tapentadol is a mu-opioid receptor agonist and a norepinephrine reuptake inhibitor. It works by binding to mu-opioid receptors in the brain and spinal cord and inhibiting the reuptake of norepinephrine.
Tapentadol is available in both immediate-release and extended-release formulations. The extended-release formulation is for around-the-clock treatment of pain and is not to be used on an as-needed basis.
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