Short Clip. Medical Animation

[JoelOtron]

Its pretty, but what's it a medical animation of? I dont recognize any of the elements. Are we inside a syringe where a drug is being administered? Maybe dust particles in bronchioles? Don't quite get it.

[InTheCity]

Its pretty, but what's it a medical animation of? I dont recognize any of the elements. Are we inside a syringe where a drug is being administered? Maybe dust particles in bronchioles? Don't quite get it.
It's a glutamate receptor in the brain.
I can't say too much about the nature of the drugs used, client privacy etc.

[JoelOtron]

Interesting.


The glutamate recetor should probably embedded in the membrane on the receiving end a nerve synapse. Wouldnt be floating around in a tube and wouldnt be a sphere with dancing spheres within (I assume thats the receptor?) Anyway--most likely your working from a storyboard and sometimes the marketing people at the pharma companies dont have their facts straight.

[InTheCity]

A quick update on the look and feel;

http://www.project1media.com/cl2/allpreview.mov

[jamiearonson]

I like it. It looks very organic. I see you have used your cranal noise technique that you posted in the underwater thread. I like the wandering camera move as well. I did seem to notice that the particles coming down the tube seem to be much brighter and more saturated when they are futher away from the camera. When they pass by they seem to get real murky.

I know this is a WIP but is motion blur out of the picture? I think it would add a lot to the finished piece expecially for the particles close to the camera.

Overall I like the look, great texturing.

[InTheCity]

I like it. It looks very organic. I see you have used your cranal noise technique that you posted in the underwater thread. I like the wandering camera move as well. I did seem to notice that the particles coming down the tube seem to be much brighter and more saturated when they are futher away from the camera. When they pass by they seem to get real murky.

I know this is a WIP but is motion blur out of the picture? I think it would add a lot to the finished piece expecially for the particles close to the camera.

Overall I like the look, great texturing.
Thanks, there's been alot of fixes since the original at the top, particle collisions are slower, more accurate, start at different times. A new volumetric light has replaced the old one, which doesn't wash out the scene and also there's some additional detail in the texture.
And yes, I actually have 5pass Motion Blur on the final.

I'll post an update render on Monday when it's finished.

Thanks for checking it out, always good to hear feedback

[NWoolridge]

Interesting.

The glutamate recetor should probably embedded in the membrane on the receiving end a nerve synapse. Wouldnt be floating around in a tube and wouldnt be a sphere with dancing spheres within (I assume thats the receptor?) Anyway--most likely your working from a storyboard and sometimes the marketing people at the pharma companies dont have their facts straight.

I found it puzzling, too.... I think it must be representing the interior of an axon or dendrite, showing a pool of glutamate receptors (or a neurotransmitter like glutamate itself) in intracellular vesicles. Some signal arrives--the cascading spheres--and the vesicles exocytose into the synaptic cleft.

If I can pick a few nits... The signal spheres are tumbling along like bits of wood in a stream; at this scale, molecules move via a chaotic, diffusive motion (brownian motion) that is very unlike motion governed by our macroscopic physics. A great exemplar of that sort of work is Drew Berry's animations:

http://www.wehi.edu.au/education/wehi-tv/movies.html

See the DNA and CSF animations, especially. You can't completely emulate microscopic physics, because it really is confusing chaos, but making the motion look less directed will help...

There is one match cut that is very confusing, where the vesicle "docks" on the intracellular side of the cell membrane, then we are suddenly on the outside seeing the exocytotic pore. I can interpret that, because I am very familiar with the subject matter, but I think most people will find that passage confusing...

HTH

Nick

[InTheCity]

You're right, It's the inside of an Axon terminal showing the Ions interacting with the vesicle.

The shot I posted is about revision 3, which is on my home computer. We're up to about revision 6 and lots has changed. The particles as you say have a much more irregular motion, they don't cling to the vesicle anymore, instead they hover above and flash mutiple times to show communication between the two. Then in a much more medically correct way, you see the gates opening much like in the second scene. Obviously there we'll cut to show the next stage.

[ThorFury]

Hey InTheCity,

This looks good so far, my only comment would be that if the signal spheres are triggering the vesicles to release, then the signal is probably calcium, which enters through channels right there in the terminal instead of farther up the axon. If it's not supposed to be calcium, then I'll just shut up now.

Gregg

[InTheCity]

Hey InTheCity,

This looks good so far, my only comment would be that if the signal spheres are triggering the vesicles to release, then the signal is probably calcium, which enters through channels right there in the terminal instead of farther up the axon. If it's not supposed to be calcium, then I'll just shut up now.

Gregg
:wise: You guys are pretty damn smart, do you actually research this stuff?
Although I don't doubt that you're right, it would be an awful long task replacing it..

If you don't say anything, neither will I.

I base all this on storyboards, which may not be accurate. But what is accurate? especially when you're talking about things that have never actually been seen by the human eye. According to the description; They're 1 micron in length, can we even get that close?

[ThorFury]

I definitely don't go out of my way to research this stuff, but they kind of force you to learn it in med school. And I promise not to say anything.

[JoelOtron]

I found it puzzling, too.... I think it must be representing the interior of an axon or dendrite, showing a pool of glutamate receptors (or a neurotransmitter like glutamate itself) in intracellular vesicles. Some signal arrives--the cascading spheres--and the vesicles exocytose into the synaptic cleft.

If I can pick a few nits... The signal spheres are tumbling along like bits of wood in a stream; at this scale, molecules move via a chaotic, diffusive motion (brownian motion) that is very unlike motion governed by our macroscopic physics. A great exemplar of that sort of work is Drew Berry's animations:

http://www.wehi.edu.au/education/wehi-tv/movies.html

See the DNA and CSF animations, especially. You can't completely emulate microscopic physics, because it really is confusing chaos, but making the motion look less directed will help...

There is one match cut that is very confusing, where the vesicle "docks" on the intracellular side of the cell membrane, then we are suddenly on the outside seeing the exocytotic pore. I can interpret that, because I am very familiar with the subject matter, but I think most people will find that passage confusing...

HTH

Nick

You beat me to it Nick :)

It occurred to me earlier today that we were looking at vesicles fusing with the membrane and the \"dancing balls " were some kind of neurotransmitter --I guess Glutamate! (yeah--I've been thinking about it)

Interesting as it took me off guard. You see so many MOAs that happen outside the neuron--I dont remember seeing any showing vesicles inside the Axon.

Cool- In The City :)

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